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<p>Symbiotic flora exhibits a strong association with the pathogenesis of allergic disorders. Certain <i>Bacteroides</i> species have demonstrated potential in ameliorating allergic conditions. However, the specific role of <i>Bacteroides uniformis</i> in allergic asthma and its underlying mechanisms remain incompletely understood. This study demonstrates that oral administration of <i>B.uniformis</i> IM01 significantly enhanced the production of indole-3-acetic acid (IAA), suppressed airway inflammatory cell airway infiltration and aberrant T helper 2 (Th2) immune responses, and improved the epithelial barrier function in a murine model of asthma. Mechanistically, <i>B.uniformis</i> IM01 upregulated tryptophan metabolism, elevating IAA levels in both colon and serum, which activated the aryl hydrocarbon receptor (AhR) and induced interleukin-22 (IL-22) production. Activated AhR may inhibit NF-κB/NLRP3 signaling pathway and facilitate the splenic differentiation of Foxp3<sup>+</sup> regulatory T cells (Tregs), thus attenuating lung barrier dysfunction and improving allergic asthma symptoms. In summary, our results revealed that <i>B.uniformis</i> IM01 upregulated production of IAA to activate AhR leading to inhibited NF-κB/NLRP3-mediated immune responses, and ameliorated allergic asthma through the gut-lung axis.</p> Graphical abstract <p><i>B.uniformis</i> IM01 upregulated production of IAA to active AhR leading to inhibited NF-κB/NLRP3-mediated immune responses, and ameliorated allergic asthma symptoms through the gut-lung axis.</p> <p></p>

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B.uniformis IM01-derived IAA alleviates asthma via AhR/NLRP3 pathways in mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月6日

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  • Yujia He,
  • Tao Yang,
  • Jielan Mi,
  • Siqin He,
  • Zhihan Yang,
  • Simin Lu,
  • Kun Yue,
  • Yuanming Huang,
  • Liqiong Song,
  • Yuchun Xiao,
  • Zhihong Ren

摘要

Symbiotic flora exhibits a strong association with the pathogenesis of allergic disorders. Certain Bacteroides species have demonstrated potential in ameliorating allergic conditions. However, the specific role of Bacteroides uniformis in allergic asthma and its underlying mechanisms remain incompletely understood. This study demonstrates that oral administration of B.uniformis IM01 significantly enhanced the production of indole-3-acetic acid (IAA), suppressed airway inflammatory cell airway infiltration and aberrant T helper 2 (Th2) immune responses, and improved the epithelial barrier function in a murine model of asthma. Mechanistically, B.uniformis IM01 upregulated tryptophan metabolism, elevating IAA levels in both colon and serum, which activated the aryl hydrocarbon receptor (AhR) and induced interleukin-22 (IL-22) production. Activated AhR may inhibit NF-κB/NLRP3 signaling pathway and facilitate the splenic differentiation of Foxp3+ regulatory T cells (Tregs), thus attenuating lung barrier dysfunction and improving allergic asthma symptoms. In summary, our results revealed that B.uniformis IM01 upregulated production of IAA to activate AhR leading to inhibited NF-κB/NLRP3-mediated immune responses, and ameliorated allergic asthma through the gut-lung axis.

Graphical abstract

B.uniformis IM01 upregulated production of IAA to active AhR leading to inhibited NF-κB/NLRP3-mediated immune responses, and ameliorated allergic asthma symptoms through the gut-lung axis.