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Background <p>Recent studies have suggested that alterations in natural killer (NK) cell function may contribute to the development of COVID-19. Additionally, dysregulated NK cells may increase susceptibility to COVID-19 and affect the severity of the infection.</p> Purpose <p>This study aimed to explore the causal relationship between NK cell-related immune traits and the risk of COVID-19 infection.</p> Methods <p>A two-sample Mendelian randomization (MR) analysis was conducted to explore the causal relationship between NK cell-related immune traits and COVID-19. Exposure and outcome data were analyzed using the two-sample Mendelian Randomization (MR) method.</p> Results <p>The results of the study suggest that there is a causal relationship between the absolute number of NK cells in COVID-19 infection and the risk of severe illness. The results also demonstrated that the morphological parameters are not causally related to COVID-19 infection but were causally related to COVID-19 hospitalization and COVID-19 severity.</p> Conclusion <p>This finding has important implications for our understanding of the pathophysiology of COVID-19 and the development of future therapies and interventions for this disease.</p>

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The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity

  • 期刊论文

  • 发表日期：

    2025年2月13日

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  • Kaili Yang,
  • Jun Quan,
  • Zhi Liu,
  • Zebing Huang,
  • Shuyi Wang,
  • Jia Li,
  • Aiming Wang,
  • Li Wu,
  • Songman Yu,
  • Panpan Yi,
  • Meifang Xiao,
  • Yayu Chen,
  • Xingwang Hu,
  • Shushan Zhao

摘要

Background

Recent studies have suggested that alterations in natural killer (NK) cell function may contribute to the development of COVID-19. Additionally, dysregulated NK cells may increase susceptibility to COVID-19 and affect the severity of the infection.

Purpose

This study aimed to explore the causal relationship between NK cell-related immune traits and the risk of COVID-19 infection.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted to explore the causal relationship between NK cell-related immune traits and COVID-19. Exposure and outcome data were analyzed using the two-sample Mendelian Randomization (MR) method.

Results

The results of the study suggest that there is a causal relationship between the absolute number of NK cells in COVID-19 infection and the risk of severe illness. The results also demonstrated that the morphological parameters are not causally related to COVID-19 infection but were causally related to COVID-19 hospitalization and COVID-19 severity.

Conclusion

This finding has important implications for our understanding of the pathophysiology of COVID-19 and the development of future therapies and interventions for this disease.