In this paper, we investigate the non-existence of global solutions to the Grushin-type heat equation with nonlinear reaction terms, including cases involving memory effects: \(\begin{aligned} \left\{ \begin{array}{ll} \displaystyle {u_{t}-\Delta _{\mathcal {G}} u = k_1 \int _0^t(t-s)^{-\gamma }|u|^{p_1-1}u(s)\,\textrm{d}s} + k_2|u|^{p_2-1}u, & \\ \displaystyle {u(z,0)= u_0(z),\qquad \qquad }& \end{array} \right. \end{aligned}\) where \((z,t)\in {{\mathbb {R}}}^{N+k}\times (0,\infty )\) , \(\Delta _{\mathcal {G}}\) denotes the Grushin operator, \(u_0 \in L^1_{\textrm{loc}}({\mathbb {R}}^{N+k})\) , \(\gamma \in [0,1)\) , \(k_1,k_2 \ge 0\) , and \(p_1,p_2>1\) . We establish sharp non-existence results for global-in-time positive solutions, thereby completing the picture of global existence versus blow-up and allow us to identify the corresponding Fujita-type critical exponents in certain parameter regimes. The analysis relies on the test function method, adapted to handle both the degeneracy of the Grushin operator and the influence of the memory term.