<p>Mycotoxin contamination of staple foods, such as cereals, has gained attention due to its acute and chronic effects on human and animal health. Changes in rainfall patterns, drought, temperature, and carbon dioxide levels impact staple food production systems. Climate change increases the risk of mycotoxin contamination by altering temperature, precipitation, and growing conditions, which can lead to health risks and economic losses. It affects weather conditions, stressing plants, reducing their phytoimmunity, and making them more susceptible to fungal infections and mycotoxin contamination. To ensure future food security and safety, it is crucial to understand how climate change scenarios will impact crop production and safety. This paper reviews the occurrence of major mycotoxins in food commodities in Ethiopia, discusses their implications for economic and human health, and explores the potential effects of climate change on mycotoxin risk, highlighting research approaches for designing mitigation strategies.</p>