<p>Entanglement entropy has proven to be a powerful tool for probing renormalization group (RG) flows in quantum field theories, with c-functions derived from it serving as candidate measures of the effective number of degrees of freedom. While the monotonicity of such c-functions is well established in many settings, notable exceptions occur in theories with a mass scale. In this work, we investigate entanglement c-functions in the context of holographic RG flows, with a particular focus on flows across dimensions induced by circle compactifications. We argue that in spacetime dimensions <i>d</i> ≥ 4, standard constructions of c-functions, which rely on higher derivatives of the entanglement entropy of either a ball or a cylinder, generically lead to non-monotonic behavior. Working with known dual geometries, we argue that the non-monotonicity stems not from any pathology or curvature singularity, but from a transition in the holographic Ryu-Takayanagi surface. In compactifications from four to three dimensions, we propose a modified construction that restores monotonicity in the infrared, although a fully monotonic ultraviolet extension remains elusive. Furthermore, motivated by entanglement entropy inequalities, we conjecture a bound on the cylinder entanglement c-function, which holds in all our examples.</p>