<p>We investigate vacuum decays in the early Universe in the presence of curvature perturbations. For sufficiently large perturbations associated with over-densities, we find that the bounce solution develops an oscillating middle stage near the bubble wall. For small perturbations, we analytically show, within the thin-wall approximation, that an over-(under-) density would enhance (suppress) the vacuum decay rate for a smaller (larger) initial bubble radius. By numerically solving for the bounce solutions and evaluating the corresponding Euclidean action, we further confirm this behavior in thick-wall cases. Our results indicate that overdensities can, in general, trigger vacuum decay earlier.</p>