<p>Certain models of inert multiplets allow for semi-annihilation processes, in which two dark matter candidates annihilate to a dark matter particle and a non-dark matter particle. The existence of these processes can alleviate certain constraints and substantially modify the indirect detection signal. In this paper, we study current indirect detection constraints on the semi-annihilation of inert scalar multiplets. We show that there exist gauge numbers for which dark matter can be thermally produced and be compatible with indirect detection constraints even for very cuspy galactic dark matter density profiles.</p>